Yet, despite improved global attention to violence perpetrated against girls and women, and recent advancements in knowledge about how exactly to tackle these abuses, degrees of violence against women – including intimate partner violence, rape, female genital mutilation, trafficking, and forced marriages – stay unacceptably high, with serious effects for victims' physical and mental health. Conflict and various other humanitarian crises may exacerbate ongoing violence. Between 100 and 140 million girls and females worldwide have undergone feminine genital mutilation , with more than 3 million girls at risk of the practice every full year in Africa alone. Some 70 million girls worldwide have been married before their eighteenth birthday, many against their will.Patients were allowed to continue the analysis therapy after initial disease progression if a scientific benefit as assessed by the investigator was mentioned and the study drug had a satisfactory side-effect profile. Security assessments were executed at each clinic go to. After discontinuation of treatment, individuals were followed every three months for assessment of survival and subsequent anticancer therapy. The target response rate was defined as the amount of patients with a complete response or a partial response divided by the number of patients who underwent randomization.